"The study showed a changing pattern in the misconceptions and misinformation about COVID-19. Initially myths were largely on causes and vulnerability. It was widely speculated that black people had some immunity against COVID-19. Also, the condition was perceived to cause severe disease among the elderly. These misconceptions served as risk attenuators among Ghanaians, especially the younger generation. As the infection evolved in the country, another misconception emerged that the hot climate in Africa inhibited viral replication and transmission only to be followed by speculations and conjectures that COVID-19 was being used as a biological weapon to target developed economics. For the management of COVID-19, the use of local remedies such as Neem tree (Azadirachta indica) and herbal preparation also emerged. Myths about the efficacy of locally manufactured gin (akpeteshie) and hydroxychloroquine as prophylaxis led to abuse of such substances. Interview segments revealed the use of myths to propagate political agenda in the country. The study concludes that COVID-19 misconceptions and misinformation are widespread and cover the course of the condition. These myths necessitate culturally sensitive health communication strategies that take into account local perceptions of COVID-19 in order to tackle the circulation of misconceived messages about the pandemic in Ghana." (Abstract)